Product Overview
5-Bromo-4-fluoro-1-methyl-1H-indazole is a premium, functionally rich heterocyclic intermediate designed for advanced pharmaceutical research and development.
This compound features a strategically substituted indazole core bearing both bromo and fluoro substituents.
As well as an N1-methyl group.
This specific combination makes 5-Bromo-4-fluoro-1-methyl-1H-indazole an exceptionally versatile scaffold in medicinal chemistry.
The bromine atom serves as an excellent handle for pivotal metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), allowing for direct aryl-aryl or aryl-alkyne bond formation. Concurrently, the fluorine atom is widely used to fine-tune a molecule's electronic properties, metabolic stability, and membrane permeability, while the methyl group on the nitrogen locks the tautomeric form, providing a defined and stable regioisomer for straightforward derivatization.
Our product is synthesized under stringent quality control to ensure high chemical purity and batch-to-batch consistency. As a critical intermediate, it is ideally suited for constructing targeted libraries and optimizing lead compounds in therapeutic areas such as oncology and kinase inhibition. We supply this valuable building block with comprehensive analytical data to support your most demanding synthetic campaigns.
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Access to our dedicated medical affairs team for scientific data and clinical studies.
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Clear documentation on product indications and contraindications and Flexible ordering options and transparent pricing quotes.
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Thank you for your trust,we are committed to ensuring every order meets your expectations.We will process your order on the same day. All products undergo meticulous inspection and are packaged securely to ensure they arrive in perfect condition.
FAQ
Q: What are the primary synthetic applications of this dual-halogenated indazole?
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A: The primary application is as a multifunctional building block in drug discovery. The bromine enables rapid structural diversification via cross-coupling to install complex fragments. The fluorine atom is a key bioisostere used to modulate potency and ADMET properties. Using 5-Bromo-4-fluoro-1-methyl-1H-indazole accelerates the exploration of structure-activity relationships (SAR) around the indazole core.
Q: Why is the 1-methyl group important in this indazole derivative?
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A: The 1-methyl group prevents tautomerism (the shifting of the hydrogen between the two nitrogen atoms), which is common in unsubstituted indazoles. This provides a single, defined regioisomer, eliminating synthetic ambiguity and ensuring reproducible results in downstream reactions and biological testing.
Q: How do you ensure the quality and purity of this intermediate?
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A: We employ rigorous analytical methods, including HPLC, GC-MS, and 1H/19F NMR spectroscopy, to characterize each batch. A detailed Certificate of Analysis (CoA) is provided, confirming the identity, high chemical purity, and confirming the presence of both halogen atoms to meet the standards required for pharmaceutical R&D.
Elevate your medicinal chemistry projects with this high-quality, functionally dense intermediate. Contact us for detailed specifications, pricing, and sample availability of 5-Bromo-4-fluoro-1-methyl-1H-indazole.
Q: What's the universal lead-time for order delivery?
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A: Small production: 3-4 days Mass production :7-15days or basing on your qty.
Q: What kind of shipping do you have?
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A: DHL,FEDEX,UPS,EMS,TNT,etc.
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