Product Overview
5-Bromo-2-fluoro-m-xylene is a high-purity chemical intermediate specifically designed for advanced pharmaceutical and fine chemical synthesis.
This compound features a meta-xylene core strategically functionalized with both bromine and fluorine atoms.
This dual-halogenation pattern provides two distinct and valuable reactive sites for sequential and regioselective chemical transformations.
Making it an exceptionally versatile building block.
The bromine atom serves as an excellent handle for pivotal metal-catalyzed cross-coupling reactions, such as Suzuki or Negishi couplings, enabling the direct introduction of complex aryl or alkyl groups.
Concurrently, the fluorine atom is a crucial substituent in modern medicinal chemistry, frequently employed to fine-tune a molecule's electronic properties, metabolic stability, and binding affinity. The two methyl groups further influence the compound's steric profile and solubility. Our production of 5-Bromo-2-fluoro-m-xylene is controlled to ensure exceptional chemical purity and lot-to-lot consistency, supporting its reliable integration into complex synthetic routes for active pharmaceutical ingredients (APIs), ligands, and advanced materials.
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FAQ
Q: What is the main advantage of using this specific difunctionalized intermediate?
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A: The primary advantage is synthetic efficiency. 5-Bromo-2-fluoro-m-xylene provides two orthogonal reactive sites: the bromine for carbon-carbon bond formation via cross-coupling, and the fluorine, which can be retained as a valuable bioisostere or further manipulated under specific conditions. This allows chemists to construct complex aromatic targets in fewer steps.
Q: In which therapeutic areas is this intermediate commonly applied?
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A: As a fundamental aromatic building block, it finds utility across various domains, including the development of small-molecule drugs in oncology, CNS disorders, and inflammation. Its structure is particularly useful in constructing kinase inhibitor cores and other pharmacologically active scaffolds where halogenated aromatics are prevalent.
Q: How do you ensure the regioisomeric purity and quality of this product?
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A: We employ rigorous analytical techniques, including GC-FID and GC-MS, to confirm the precise 1,3-dimethyl-4-bromo-6-fluoro substitution pattern and ensure high chemical purity. Each batch of 5-Bromo-2-fluoro-m-xylene is supplied with a comprehensive Certificate of Analysis (CoA) detailing all relevant specifications.
Choose 5-Bromo-2-fluoro-m-xylene for your complex synthesis needs. Contact us today for detailed technical specifications, competitive pricing, and sample availability.
Q: What can you get from us?
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A: Excellent products (unique design, advance printing machine,strict quality control ) Factory direct sale (favorable and competitive price) Great service(OEM,ODM, after-sales services, fast delivery) Professional business consultation.
Q: I don't see my designed dimensions/packaging/delivery etc. Can you make a special order for us?
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A: Sure. We're truly customized. You're free to tell us whatever you want.
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