Product Overview
1,4-Dibromo-2-fluorobenzene is a premium di-halogenated aromatic intermediate engineered for sophisticated, multi-step synthetic routes in pharmaceutical and materials science research.
Its molecular architecture features two chemically distinct halogen atoms-bromines at the 1 and 4 positions and a fluorine at the 2 position-arranged to enable sequential and site-selective cross-coupling reactions.
This strategic halogen pattern is its defining advantage.
The bromine atoms are highly reactive sites for standard transition-metal-catalyzed couplings, such as Suzuki or Negishi reactions.
Meanwhile, the ortho-positioned fluorine atom exerts a strong electronic influence, potentially activating the adjacent carbon-bromine bond for faster reaction kinetics or allowing for subsequent, selective functionalization under different catalytic regimes, such as Chan-Lam coupling or nucleophilic aromatic substitution.
This compound is an indispensable starting material for constructing complex, disubstituted benzene derivatives, including unsymmetrical biaryl systems and extended π-conjugated structures. Its high purity and defined reactivity make it particularly valuable in medicinal chemistry for creating targeted compound libraries and in materials science for developing organic electronic precursors. We supply 1,4-dibromo-2-fluorobenzene with guaranteed lot-to-lot consistency and comprehensive analytical documentation to ensure reliable performance in your most demanding applications.
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FAQ
Q: What is the main synthetic benefit of the specific 1,4-dibromo-2-fluoro substitution pattern?
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A: The primary benefit is controlled, sequential functionalization. The two bromine atoms can be coupled in a stepwise manner, potentially introducing two different aryl or alkyl groups to create complex, unsymmetrical structures. The presence of the ortho fluorine can influence the reactivity order and provide an additional handle for later diversification, offering superior synthetic flexibility compared to simpler dibromobenzenes.
Q: Can the fluorine atom in this compound be used in cross-coupling reactions?
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A: While bromine is significantly more reactive in standard Pd-catalyzed couplings, the fluorine atom can participate in specific reactions, such as SNAr with strong nucleophiles or specialized Pd-catalysis designed for C-F bond activation. However, its primary role in many schemes is as a stable substituent that modulates electronic properties and can be leveraged for late-stage diversification after the bromine sites have been utilized.
Q: How do you ensure the isomeric purity of your 1,4-dibromo-2-fluorobenzene?
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A: We employ advanced chromatographic and spectroscopic techniques, including high-resolution GC and GC-MS, to confirm the exact 1,4-dibromo-2-fluoro regioisomer and ensure the absence of other dibromobenzene isomers. Each batch is supplied with a Certificate of Analysis detailing the isomeric purity (>99% by GC), ensuring you receive a precisely defined compound for your synthesis.
Q: How to place your order:
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A: 1. Send us your order list (models/quantities/colors)
2. we will send you PROFORMA INVOICE (PI) with shipping cost and Payment information for your confirmation.
3. You arrange payment after you confirmed proforma invoice, we will arrange production after received your payment notice.
Specific delivery date depends on your specific needs, normally delivery in 1-3 days.
4.We will arrange delivery after your payment arrived and goods ready,and at the same time we will tell you goods tracking number so that you could know your goods condition by this number from courier site.
5.You will receive your order in about 3-5 days after goods ship out.
Q: Can I get any discount?
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A: The price is depend on quantity,we can offer you discount according to your order quantity. lfyou are buying in bulk for an occasion, We offer you wholesale price. We also have promotionsseveral times a year.
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