Product Overview
(R)-4-Benzyl-2-oxazolidinone is a fundamental and high-purity chiral auxiliary essential for modern asymmetric synthesis, most notably in the widely adopted Evans aldol reaction.
This enantiomerically pure (R)-configured compound serves as a powerful and versatile template for the stereoselective construction of complex molecules with defined stereochemistry.
When acylated, it forms a chiral enolate that undergoes highly diastereoselective aldol additions, reliably installing new chiral centers with exceptional predictability.
Its efficacy makes *(R)-4-Benzyl-2-oxazolidinone* a cornerstone in the synthesis of complex natural products and Active Pharmaceutical Ingredients (APIs), particularly for constructing polyketide fragments and other oxygenated stereocenters.
We supply *(R)-4-Benzyl-2-oxazolidinone* with guaranteed high enantiomeric excess and chemical purity, ensuring reproducible and high-yielding results in your critical synthetic sequences.
Its utility extends beyond the classic aldol reaction to various alkylations and functional group transformations, making it an indispensable and reusable tool for medicinal chemists and process researchers focused on developing stereochemically defined therapeutic candidates.
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FAQ
Q: Why is the (R)-enantiomer of this auxiliary more commonly used than the (S) form?
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A: The choice between enantiomers dictates the absolute stereochemistry of the final product. *(R)-4-Benzyl-2-oxazolidinone* is extensively used because it leads to the predictable formation of one specific stereoisomer in the Evans aldol reaction, which often corresponds to the desired configuration found in numerous target molecules. The (S)-enantiomer is equally available but provides the mirror-image product.
Q: How is the chiral purity of your product ensured?
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A: We employ chiral HPLC or SFC analysis to rigorously confirm the high enantiomeric excess (e.e. >99%) of each batch. Combined with standard techniques like NMR for structural verification, we guarantee that our *(R)-4-Benzyl-2-oxazolidinone* delivers the precise stereochemical fidelity required for successful asymmetric induction.
Q: Can you provide related derivatives or custom acylated versions of this auxiliary?
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A: Yes. In addition to the standard auxiliary, we offer custom synthesis services to provide specific pre-acylated derivatives (e.g., propionyl, acetyl) of *(R)-4-Benzyl-2-oxazolidinone*, ready for immediate use in your aldol or alkylation reactions, saving valuable time in your R&D workflow.
Choose this industry-standard chiral auxiliary for your most demanding syntheses. Contact us for specifications, pricing, and technical support.
Q: Free sample service
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A: Samples can be free.
Sample which we have in stock, will be sent to you within 1 working day.
OEM sample, will be sent to you within 3 working days.
Q: Direct factory, Competitive price
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A: We are manufacturer.Factory price, various products we can source for you.
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